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Stemolecule™ CHIR99021(GSK-3β抑製劑)

Stemolecule™ CHIR99021(GSK-3β抑製劑)

簡要描述:

Stemolecule™ CHIR99021(GSK-3β抑製劑):氨基嘧啶CHIR99021是目前為止報道的選擇性Z強的GSK-3β抑製劑。與其他強效的GSK-3抑製劑相比,CHIR99021不會交叉抑製細胞周期蛋白依賴性激酶(CDKs),對GSK-3β的選擇性是對CDKs的350倍。

產品時間:2017-05-14

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Stemolecule™ CHIR99021GSK-3β抑製劑)

 

產品關鍵詞:

GSK-3βnaïve stem cells 初始幹細胞;neural progenitor cells 神經祖細胞;WH-4-023Y27632PD0325901CAS252917-06-9

 

產品描述:

氨基嘧啶CHIR99021是目前為止報道的選擇性zui強的GSK-3β抑製劑。與其他強效的GSK-3抑製劑相比,CHIR99021不會交叉抑製細胞周期蛋白依賴性激酶(CDKs),對GSK-3β的選擇性是對CDKs350倍。與抑製MAPK來源的分化誘導信號聯合,使用CHIR99021阻斷 GSK-3β信號使得胚胎幹細胞能自我更新。

 

產品特性

  1. 同義名:6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile
  2. 分子式:C22H18Cl2N8
  3. 分子量:465.34 g/mol
  4. CAS NO252917-06-9
  5. 純度:>95%HPLC
  6. 外觀:Off-white solid
  7. 溶解性:DMSO
  8. 保存和穩定性:粉末4 °C避光保存,重溶後的儲存液分裝後-20 °C保存,6個月穩定。
  9. 質量控製:HPLC測定純度,MS測定準確分子量,CHIR99021對小鼠胚胎幹細胞的細胞毒性測試。
  10. 結構圖:

 

訂購信息:原裝正品,歡迎訂購,:

品牌

名稱

貨號

規格

Stemgent

Stemolecule™ CHIR99021

04-0004

2 mg

Stemgent

Stemolecule™ CHIR99021

04-0004-10

10 mg

Stemgent

Stemolecule™ CHIR99021

04-0004-02

2 mg (10 mM)

 

引用文獻:

  • Xia N; Zhang P; Fang F; Wang Z; Rothstein M; Agulo B; Chiang R; Taylor J; Reijo Pera RA. "Transcriptional comparison of human induced and primary midbrain dopaminergic neurons." Scientific Reports. 6:20270. doi:10.1038/srep20270 (2016)
  • Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. "Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules." Stem Cells International 2016:4304916 (2016)
  • Zhu S; Russ HA; Wang X; Zhang M; Ma T; Xu T; Tang S; Hebrok M; Deng S. "Human pancreatic beta-like cells converted from fibroblasts." Nature Commun 7:10080 (2016)
  • Titmarsh DM; Glass NR; Mills RJ; Hidalgo A; Volvetang EJ; Porrello ER; Hudson JE; Cooper-White JJ. "Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays." Sci Rep 6:24637 (2016)
  • Liu G. "No detection of potential cancer risk for free-viral reprogrammed stem cell-derived dopaminergic neurons from adult mice fibroblasts." J Stem Cell Res Ther 5:286 (2015)
  • Fonoudi H; Ansari H; Abbasalizadeh S; Laruani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw SD; Harvey RP; Aghdami N; Baharvand H. "A universal and robust integrated platform for the scalable production of human coardiomhyocytes from pluripotent stem cells." Stem Cells Trans Med 4:1482 (2015)
  • Yang J; Kaur K; Ong LL; Eisenberg CA; Eisenberg LM. "Inhibition of G9a histone methyltransferase converts bbone marrow mesenchymal stem cells to cardiac competent progenitors." Stem Cells International Article 270428 (2015) doi:10.1155/2015/270428
  • Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)
  • DeRosa BA; Belle KC; Thomas BJ; Cukier HN; Pericak-Vance MA; Vance JM; Dykxhoom DM. "hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells." Mol Cell Neurosci 68:244 (2015)
  • Tan H-K; Toh C-XDl Ma D; Yang B; Liu TM; Lu J; Wong C-W; Tan T-K; Li H; SYn C; Tan E-L; Lim B; Lim Y-P; Cook SA; Loh Y-H. "Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking." Stem Cells Trans Medicine 3:586 (2014)
  • Ying, Q., Tai, C. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. Journal of Cell Science 126, 1093 – 1098.(2013)
  • Youn H; Kim S-H; Choi KA; Kim S. "Characterization of Oct4-GFP spermatogonial stem cell line and its applicationo in the reprogramming studies." J Cell Biochem 114:920 (2013)
  • Blauwkamp TA; Nigam S; Ardehali R; Weissman IL; Nusse R. Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nature Communications 3:1070 (2012).
  • Lian, X., Hsiao, C., Wilson, G, Zhu, K., Hazeltine, L.B., Azarin, S.M., Raval, K.K., Zhang, J., Kamp, T.J., and Palecek, S.P. (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci USA 109: E1848 (2012)
  • Moraveji S-F; Attari F; Shahverdi A; Sepehri H; Farrokhi A; Hassani S; Fonoudi H; Aghdami N; Baharvand H. "Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis." Human Reproduction 27:2312 (2012)
  • Nagy, K., Sung, H-K., Zhang, P., Laflamme, S., Vincent, P, Agha-Mohammadi, S., Woltjen, K., Monetti, C., Michael, I. P., Smith, L. C., Nagy, A. Induced Pluripotent Stem Cell Lines Derive from Equine Fibroblasts. Stem Cell Reviews and Reports 7:693 (2011).
  • Wang, B., Miyagoe-Suzuki, Y., Yada, E., Ito, N., Nishiyama, T., Nakamura, M., Ono, Y., Motohashi, N., Segawa, M., Masuda, S., Takeda, S. Reprogramming Efficiency and Quality of Induced Pluripotent Stem Cells (iPSCs) Generated from Muscle-derived Fibroblasts of MDX Mice at Different Ages. PLOS Currents Muscular Dystrophy. 2011 Oct 27 . Edition 1. doi: 10.1371/currents.RRN1274 .
  • Mack, A., Kroboth, S., Rajesh, D., Wang, W. B. Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-Integrating Episomal Vectors. PLoS One; 6(11): e27956.(2011)
  • Li, W., Zhou, H., Abujarour, R., Zhu, S., Young Joo, J., Lin, T., Hao, E., Schöler, H.R., Hayek, A., Ding, S. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27: 2992-3000.
  • Chiang P-M; Wong PC. "Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: Essential role of bone morphogenetic protein 4." Development 138: 2833-2843 (2011)

 

 — —Written/Edited by V. Shallan【版權歸MKBio香蕉视频app官方网站入口所有】

 

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Stemolecule™ CHIR99021(GSK-3β抑製劑)

Stemolecule™ CHIR99021(GSK-3β抑製劑)

Stemolecule™ CHIR99021(GSK-3β抑製劑)

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